Hydrazine hydrate (1:1) → HCID 59280221, compound

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Reaction Steps

7.9 g (40.0 mmol) of the compound from Example 13A are dissolved in 45 ml of ethanol. The solution is divided into three reaction vessels, and in each case 6.6 g (131.9 mmol) of hydrazine hydrate are added. Each reaction mixture is reacted in each case for 4 h at 170° C. in a single-mode microwave oven (CEM Explorer). The three mixtures are then combined, and the solvent is removed. The residue is taken up in ethyl acetate and washed once with saturated sodium bicarbonate solution. The aqueous phase is reextracted once with ethyl acetate. The two ethyl acetate phases are combined and washed once with saturated sodium chloride solution. The mixture is dried over magnesium sulfate and the solvent is removed. The residue is triturated with petroleum ether, and the solid obtained is filtered off and dried under high vacuum.

Provenance & Evidence