Cyclohexanecarboxaldehyde → HCID 24897730, compound

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Reaction Steps

11.2 mg (100 μmol) of cyclohexanecarbaldehyde are initially charged, 34.0 mg (100 mol) of the compound from Example 4A, dissolved in 0.6 ml of ethanol, and 25.8 mg (200 μmol) of diisopropylethylamine are added and the mixture is stirred at RT overnight. 5.7 mg (150 μmol) of sodium borohydride are then added, and the mixture is shaken at RT for 3 h. 100 μl of water are then added, and the mixture is concentrated. The residue is taken up in DMSO, the precipitate is filtered off and the filtrate is purified by preparative HPLC (Method 4).

Provenance & Evidence