反应详情

温度

80 °C

A mixture of 7-chloro-5-(tetrahydro-2H-thiopyran-4-yl)pyrazolo[1,5-a]pyrimidine (Int-1c, 1.52 g, 6.0 mmol) in a solution of ammonia in MeOH (7 N, 20 mL) was heated in sealed vessel at 80° C. for 5 h. The reaction mixture was cooled down and concentrated. The residue was dried in high vacuum and used for the next step without further purification. LC/MS RT=0.92 Min (5 min method). Mass calculated for, M+H 235.09, observed 235.09.

1. temperatureThe reaction mixture was cooled down
2. concentrationconcentrated
3. customThe residue was dried in high vacuum
4. customused for the next step without further purification
5. customLC/MS RT=0.92 Min (5 min method)