Ammonia → HCID 66584856, compound

HRID 1913208Notes

Reaction equation

HRID 1913208 reaction equation
Cl[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([CH:11]2[CH2:16][CH2:15][S:14][CH2:13][CH2:12]2)[CH:3]=1.[NH3:17]>CO>[S:14]1[CH2:15][CH2:16][CH:11]([C:4]2[CH:3]=[C:2]([NH2:17])[N:7]3[N:8]=[CH:9][CH:10]=[C:6]3[N:5]=2)[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 866678347-Chloro-5-(tetrahydro-2H-thiopyran-4-yl)pyrazolo[1,5-a]pyrimidine

Product 1

HCID 66584856HCID 66584856, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 7-chloro-5-(tetrahydro-2H-thiopyran-4-yl)pyrazolo[1,5-a]pyrimidine (Int-1c, 1.52 g, 6.0 mmol) in a solution of ammonia in MeOH (7 N, 20 mL) was heated in sealed vessel at 80° C. for 5 h. The reaction mixture was cooled down and concentrated. The residue was dried in high vacuum and used for the next step without further purification. LC/MS RT=0.92 Min (5 min method). Mass calculated for, M+H 235.09, observed 235.09.

Workup

  1. temperatureThe reaction mixture was cooled down
  2. concentrationconcentrated
  3. customThe residue was dried in high vacuum
  4. customused for the next step without further purification
  5. customLC/MS RT=0.92 Min (5 min method)

Sources & evidence

ORD record
ord-3842b0faf4ee4e919ff1ee8b0818101b
Source dataset
uspto-grants-2013_12
Patent number
US08609675B2

Reaction notes

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