Stannane, tributyl(1-ethoxyethenyl)- → HCID 66900287, compound

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Reaction Conditions

Reaction Steps

A mixture of 3-(quinolin-3-yl)-5-(1,1-dioxo-tetrahydro-2H-thiopyran-4-yl)-N,N-bis((2-(trimethylsilyl)ethoxy)methyl)pyrazolo[1,5-a]pyrimidin-7-amine (Int-2b, 210 mg, 0.28 mmol), tributyl(1-ethoxyvinyl)stannane (310 mg, 0.84 mmol) and Pd(Ph3P)4 (31 mg, 0.028 mmol) in anhydrous dioxane (5.0 mL) was heated under argon at 100° C. for 24 h, cooled and concentrated. The residue purified by Biotage (CH2Cl2/EtOAc, 20:1 to 4:1) to give 169 mg (83%) of the title compound as a light brown solid. LC/MS RT=2.58 min (5 min method). Mass calculated for, M+H 724.33, observed 724.33.

Provenance & Evidence