N-bromobutanimide → HCID 66896758, compound

Participants

Reaction Steps

To a solution of 3-(4-phenyl-3-pyridyl)-5-(1,1-dioxo-tetrahydro-2H-thiopyran-4-yl)-N,N-bis((2-(trimethylsilyl)ethoxy)methyl)pyrazolo[1,5-a]pyrimidin-7-amine (Int-3a, 190 mg, 0.29 mmol) in acetonitrile (5 mL) was added NBS (51 mg, 0.29 eq). The mixture was stirred at rt for 2 h and concentrated. The residue was purified by Biotage (CH2Cl2/EtOAc, 20:1 to 4:1) to give 210 mg (99%) of the title compound as a light brown solid (Int-3b). LC/MS tR=2.55 (5 min method). Mass calculated for, M+H 757.20, observed 757.20 & 759.20 (doublet for Br).

Provenance & Evidence