反应详情

温度

100 °C

To a 50 mL round-bottom flask containing ethyl 4-(4-ethoxy-2,4-dioxobutyl)cyclohexanecarboxylate (Int-4e, 2.33 g, 8.19 mmol) was added 3-amino-1H-pyrazole (681 mg, 8.19 mmol). The flask was heated via heat gun to ensure mixing of the oils, and then the reaction was shaken at 100° C. for 18 hours. After 18 hours, the resulting solid was taken up in EtOH and then the solvent was removed in vacuo to dry product. The product was then pumped dry on high vacuum overnight to further dry the product. The compound was taken on without further purification.

1. temperatureThe flask was heated
2. temperaturevia heat gun
3. additionto ensure mixing of the oils
4. waitAfter 18 hours
5. customthe solvent was removed in vacuo to dry product
6. customThe product was then pumped dry on high vacuum overnight
7. customto further dry the product
8. customThe compound was taken on without further purification