N-Iodosuccinimide → HCID 69929724, compound

Participants

Reaction Steps

To a 100 mL round-bottom flask was charged ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate (Int-4i, 2.64 g, 4.69 mmol) and N-iodosuccinimide (1.16 g, 5.16 mmol). To this mixture was added MeCN (40 mL). The resulting solution was stirred at room temperature overnight. After 18 hours, the reaction was reduced in vacuo and the residue was purified via silica gel chromatography to yield the title compound. Yield=2.94 g.

Provenance & Evidence