N-bromobutanimide → HCID 69929544, compound

Participants

Reaction Steps

To a 20 mL scintillation vial was charged ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate (Int-4l, 265 mg, 0.37 mmol) and N-bromosuccinimide (80 mg, 0.45 mmol). To this was added acetonitrile (5 mL). The resulting solution was stirred at room temperature for 18 hours. At 18 hours, the reaction was reduced in vacuo and the residue was purified via silica gel chromatography to yield the title compound as yellow oil. Yield=255 mg.

Provenance & Evidence