Stannane, tributyl(1-ethoxyethenyl)- → HCID 66896579, compound

Participants

Reaction Conditions

Reaction Steps

To a 2-5 mL microwave vessel was charged ethyl 4-((7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)methyl)cyclohexanecarboxylate (Int-4m, 150 mg, 0.19 mmol), Pd(PPh3)4 (33 mg, 0.029 mmol), tributyl (1-ethoxyvinyl)tin (190 μL, 0.56 mmol), and 1,4-dioxane (2 mL). The vial was flushed with argon and sealed. The reaction was heated to 100° C. for 18 hours. After 18 hours, the solvent was removed in vacuo and the residue was purified via silica gel chromatography to yield the title compound. Yield=113 mg.

Provenance & Evidence