N-bromobutanimide → Ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-6-bromo-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate

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To a solution of ethyl 2-(4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexyl)acetate (Int-5n, 512 mg, 715 μmol) in acetonitrile (15 mL) was added N-bromosuccinimide (153 mg, 858 μmol). The resulting solution was allowed to stir at room temperature for 18 hours. After 18 hours, the solvent was reduced in vacuo and the title compound was purified via silica gel chromatography.

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