HCID 66879223, compound → HCID 178450659, compound

Participants

Reaction Conditions

Reaction Steps

4-(2-Ethoxycarbonyl-acetyl)-cyclohexanecarboxylic acid t-butyl ester (8.5 g) and 3-amino-1H-pyrazole (Int-7a, 26.5 mmol, 2.2 g) were mixed and heated neat at 100° C. for 16 hours. The resulting residue was dissolved in dichloromethane (100 mL) and concentrated in vacuo to remove water formed during cyclization. This solid was taken forward without further purification. LC-MS: 318 [M+H].

Provenance & Evidence