HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyldiazomethane → tert-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | [1-(tert-Butoxycarbonyl)piperidin-4-yl]acetic acid | HCID 1512539 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | tert-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate | HCID 1514280 | — |
Reaction Steps
At 0° C., TMSCHN2 (2.0 M in ether, 15 mL) was added dropwise to a mixture of 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid (6272 mg, 25.78 mmoL) in toluene (60 mL) and MeOH (60 mL). After stirring at room temperature for 1 h, the mixture was concentrated. The crude tert-butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate (Int-12a) was pure enough without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609675B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-177033c838964100b81cc99115d96f0e |
| Source note | uspto-grants-2013_12 |