Chlorosuccinimide → HCID 135998744, compound

Participants

Reaction Steps

NCS (3.7 mg, 0.027 mmoL) was added to a solution of (R)-2-hydroxy-1-(4-(3-(6-phenylpyridin-3-yl)-8H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidin-5-yl)piperidin-1-yl)propan-1-one (25, prepared in Example 15) (12.8 mg, 0.027 mmoL) in DMF (1 mL). The mixture was stirred at room temperature for 3 days. Purification by prep-LC afforded (R)-1-(4-(6-chloro-3-(6-phenylpyridin-3-yl)-8H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidin-5-yl)piperidin-1-yl)-2-hydroxypropan-1-one (34): LCMS tR=3.70 Min (10 min run, UV254nm). Mass calculated for, M+500.1, observed 501.5 (M+H).

Provenance & Evidence