HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl vinyl ketone → 1-{4-[2-(2-Fluoro-phenyl)-5-methyl-pyrrol-1-yl]-benzenesulfonyl}-piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl vinyl ketone | HCID 6570 | — |
| Reactant | o-Fluorobenzaldehyde | HCID 67970 | — |
| Reactant | 4-(Piperidine-1-sulfonyl)aniline | HCID 236648 | — |
| Product | 1-{4-[2-(2-Fluoro-phenyl)-5-methyl-pyrrol-1-yl]-benzenesulfonyl}-piperidine | HCID 68487442 | — |
Reaction Steps
2-Fluorobenzaldehyde and but-3-en-2-one were treated according to the procedure outlined in General Procedure C followed by subjecting the resulting product to conditions outlined in General Procedure D along with p-piperidinylsulfonyl phenylamine to obtain the titled compound. 1H NMR (CDCl3) δ ppm 1.42-1.65 (6H), 2.15 (3H), 2.95 (4H), 6.15 (1H), 6.40 (1H), 6.65-7.90 (8H); MS (ESI) m/z 399 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609713B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-5e59df5a297d4d2a86ff2d5d61380b94 |
| Source note | uspto-grants-2013_12 |