2-Bromo-5-methoxypyridine → 2-(5-Methylpyridin-2-yl)acetic acid

HRID 1913412Notes

Reaction equation

HRID 1913412 reaction equation
CO[C:3]1[CH:4]=[CH:5][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[N:7][CH:8]=1.Br[C:14]1C=CC(OC)=CN=1>>[CH3:14][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[N:7][CH:8]=1

Participants

3

Reactant 2

HCID 111481512-Bromo-5-methoxypyridineHCID 584384902-(5-Methoxypyridin-2-yl)acetic acid

Product 1

HCID 190662662-(5-Methylpyridin-2-yl)acetic acid

Procedure

(5-Methylpyridin-2-yl)acetic acid was prepared using analogous procedures to those used for the preparation of (5-methoxypyridin-2-yl)acetic acid (SM-1ab) substituting 2-bromo-5-methylpyridine for 2-bromo-5-methoxypyridine.

Sources & evidence

ORD record
ord-17d19c374401429c8a358a7451c928f7
Source dataset
uspto-grants-2013_12
Patent number
US08609680B2

Reaction notes

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