Sodium Hydroxide → HCID 21482187, compound

Participants

Reaction Steps

To a solution of (2-acetylamino-4-methoxy-phenyl)-acetic acid methyl ester (49 mg, 0.21 mmol) in 1.5 mL of methanol was added aqueous 1N NaOH (1.5 mL, 1.5 mmol). The mixture was stirred for 3 h at room temperature. and the pH was adjusted to ˜4 by the addition of Amberlyst 15 ion-exchange resin. After filtration, the filtrate was concentrated to give 46 mg (100%) of 2-acetylamino-4-methoxy-phenyl)-acetic acid which was used without further purification.

Provenance & Evidence