2-(2,5-Dichloropyrimidin-4-ylamino)-N-methylbenzamide → 2-{5-Chloro-2-[3-(2,2-difluoro-ethyl)-8-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]-pyrimidin-4-ylamino}-N-methyl-benzamide
Reaction equation
[Cl:19][c:20]1[n:21][cH:22][c:23]([Cl:37])[c:24]([NH:26][c:27]2[c:28]([C:29](=[O:30])[NH:31][CH3:32])[cH:33][cH:34][cH:35][cH:36]2)[n:25]1.[F:1][CH:2]([CH2:3][N:4]1[CH2:5][CH2:6][c:7]2[c:8]([cH:11][c:12]([NH2:17])[c:13]([O:15][CH3:16])[cH:14]2)[CH2:9][CH2:10]1)[F:18]>>[F:1][CH:2]([CH2:3][N:4]1[CH2:5][CH2:6][c:7]2[c:8]([cH:11][c:12]([NH:17][c:20]3[n:21][cH:22][c:23]([Cl:37])[c:24]([NH:26][c:27]4[c:28]([C:29](=[O:30])[NH:31][CH3:32])[cH:33][cH:34][cH:35][cH:36]4)[n:25]3)[c:13]([O:15][CH3:16])[cH:14]2)[CH2:9][CH2:10]1)[F:18]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-96b620cbfd0443baad811e51d96ce013
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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