Hydrochloric Acid → HCID 67408134, compound

Participants

Reaction Steps

To a mixture of 2-[(R)-5-(5-cyano-pyridin-2-yl)-indan-1-yl]-2,7-diaza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester (11-1a, 140 mg, 0.32 mmol) in dioxane (3 mL) was added 5 mL of 4N HCl in dioxane. The mixture was stirred for 3 hours. The volatiles were removed under reduced pressure to give the title compound as a brown solid (65 mg, 48%). MS (APCI) 345.1 (M+H)+. Retention time: 1.26 minutes XBridge C18 4.6×50 mm 5 um, 5-100% acetonitrile:water (0.1% formic acid).

Provenance & Evidence