Hydrochloric Acid → HCID 86649639, compound

Participants

Reaction Conditions

Reaction Steps

262 mg (2.24 mmol) of isopentyl nitrite and 301 mg (2.24 mmol) of copper(II) chloride were initially charged in 10.4 ml of acetonitrile. 500 mg (1.12 mmol) of the compound from Example 5A were added, and the mixture was then stirred at 60° C. for 4 h. After cooling to RT, 2.2 ml of 1N hydrochloric acid were added. The aqueous phase was extracted three times with in each case 30 ml of ethyl acetate. The combined organic phases were washed once with saturated aqueous sodium bicarbonate solution, twice with water and once with saturated aqueous sodium chloride solution and dried over sodium sulfate. After removal of the solvent, the product was used without further purification for the subsequent reaction.

Provenance & Evidence