Sodium Bicarbonate → 2-Amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-(methylthio)pyridine-3,5-dicarbonitrile

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Reaction Steps

7.30 g (32.84 mmol) of the compound from Example 43A (2-amino-6-mercapto-4-(methylthio)pyridine-3,5-dicarbonitrile), 11.03 g (131.36 mmol) of sodium bicarbonate and 9.62 g (39.41 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole were combined in 150 ml of absolute DMF and stirred at room temperature for 12 h. A solid precipitated out; this solid was filtered off with suction through a glass frit and washed three times with water and twice with diethyl ether. The residue was dried under reduced pressure.

Provenance & Evidence