Hydrochloric Acid → 2-Chloro-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-piperidin-1-ylpyridine-3,5-dicarbonitrile

Participants

Reaction Conditions

Reaction Steps

3.85 g (29.55 mmol) of isopentyl nitrite and 3.97 g (29.55 mmol) of copper(II) chloride were initially charged in 40 ml of acetonitrile, and 2.30 g (4.93 mmol) of the compound from Example 45A were added. The reaction mixture was stirred at 60° C. for 3 h. 20 ml of 1N hydrochloric acid were added to the reaction solution. The aqueous phase was extracted twice with in each case 40 ml of ethyl acetate. The combined organic phases were washed in each case once with 20 ml of saturated aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution and then dried over magnesium sulfate. The solvent was removed on a rotary evaporator. The residue was purified by column chromatography on silica gel 60 (mobile phase gradient cyclohexane:ethyl acetate=10:1→1:4).

Provenance & Evidence