Tetrabutylammonium Fluoride → HCID 44125593, compound

Participants

Reaction Steps

19 mg (0.024 mmol) of the compound from Example 33A were initially charged in 1 ml of THF, and 0.122 ml (0.122 mmol) of a 1N solution of tetrabutylammonium fluoride in THF were added. The reaction mixture was stirred at RT for 2 h and then diluted with ethyl acetate. The mixture was washed with saturated aqueous sodium bicarbonate solution. The organic phase was dried over sodium sulfate and concentrated, and the residue was purified by preparative HPLC (Chromasil, water/acetonitrile). This gave 15 mg of the product, which were purified by preparative thin-layer chromatography (dichloromethane/methanol=20/1).

Provenance & Evidence