HCID 68529434, compound → HCID 59409128, compound

HRID 1913510Notes

Reaction equation

HRID 1913510 reaction equation
[C:1]([N:4](C)[NH:5][C:6](=[O:24])[CH:7](OCC1C=CC=CC=1)[C:8]([NH:10][N:11](C(O)=O)[CH3:12])=[O:9])(O)=O>[Pd].CO>[CH3:12][NH:11][NH:10][C:8](=[O:9])[CH2:7][C:6]([NH:5][NH:4][CH3:1])=[O:24]

Participants

4

Reactant 1

HCID 68529434HCID 68529434, compound

Product 1

HCID 59409128HCID 59409128, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A flask was charged with crude N′1,N′3-dicarboxybenzyloxy-N′1,N′3-dimethylmalono-hydrazide from the step below, methanol, 10% palladium on carbon, put under an atmosphere of hydrogen, and stirred overnight. The suspension was filtered through celite and evaporated to dryness to give N′1,N′3-dimethylmalonohythazide (2.4 g; 15 mmol)

Workup

  1. filtrationThe suspension was filtered through celite
  2. customevaporated to dryness
  3. customto give N′1,N′3-dimethylmalonohythazide (2.4 g; 15 mmol)

Sources & evidence

ORD record
ord-813772e9bd3e4825956c7cb1f1740489
Source dataset
uspto-grants-2013_12
Patent number
US08609720B2

Reaction notes

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