Benzylamine → Ethyl 2-[[(phenylmethyl)amino]methyl]butanoate

Participants

Reaction Conditions

Reaction Steps

The compound obtained in Step 1 was dissolved in ethanol (7 mL). To the solution, benzylamine (2.7 mL) was added at room temperature, and the mixture was stirred at 70° C. for 17 hours. The solvent in the reaction solution was distilled off under reduced pressure, and the obtained residue was purified by silica gel column chromatography (eluting solvent: hexane-hexane/ethyl acetate=7/3) to obtain the title compound (2.34 g).

Provenance & Evidence