HCID 70869509, compound → HCID 70869430, compound

HRID 1913572Notes

Reaction equation

HRID 1913572 reaction equation
[C:1]([O:5][C:6](=[O:19])/[C:7](/[CH3:18])=[CH:8]/[C:9]1[O:10][C:11]([C:14]([O:16]C)=[O:15])=[CH:12][CH:13]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([CH:7]([CH3:18])[CH2:8][C:9]1[O:10][C:11]([C:14]([OH:16])=[O:15])=[CH:12][CH:13]=1)=[O:19])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 70869509HCID 70869509, compound

Product 1

HCID 70869430HCID 70869430, compoundYield 96.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalyst2×HCID 887MethanolSolvent

Procedure

(2E)-(5-Methoxycarbonylfuran-2-yl)-2-methylpropenoic acid tert-butyl ester (2.96 g, 11.1 mmol) was dissolved in methanol (100 ml), 10% palladium/carbon (0.3 g) was added, and the mixture was stirred at room temperature for 2 hours under a hydrogen atmosphere. After completion of the reaction, palladium/carbon was removed by celite filtration, and the solvent was evaporated under reduced pressure to give the title compound (2.72 g).

Workup

  1. customwas removed by celite filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-d7e022f8dfa64d8eaf13e81b783535ab
Source dataset
uspto-grants-2013_12
Patent number
US08609715B2

Reaction notes

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