Lithium Hydroxide → HCID 59180521, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 744 mg (1.75 mmol) of methyl 4-[(3E)-2-[2-(4-cyanophenyl)ethyl]-4-(2-methoxyphenyl)but-3-en-1-yl]benzoate in 24 ml of THF and 24 ml of water is mixed with 84 mg (3.5 mmol) of lithium hydroxide and stirred at 50° C. for 12 h. After conversion is complete, the reaction solution is diluted with diethyl ether and water, and the phases are separated. The aqueous phase is acidified with 1 M hydrochloric acid and extracted with diethyl ether. The resulting organic phase is washed with sodium chloride solution, dried over sodium sulphate and evaporated. 606 mg (1.5 mmol, 97% of theory) of the title compound are obtained.

Provenance & Evidence