反应详情

A mixture of 4-[(S)-1-(tetrahydrofuran-2-yl)methoxy]benzoic acid methyl ester (9.8 g), sodium hydroxide solution (2 N; 80 ml) and MeOH (300 ml) was stirred for 12 hours. Organic volatile fractions were removed on a rotary evaporator. The remaining aqueous phase was extracted with methyl tert-butyl ether (MTBE) and then acidified with concentrated hydrochloric acid. The resulting precipitate was filtered off and dried. The product was thus obtained with the molecular weight of 222.24 (C12H14O4); MS (ESI): 223 (M+H+).

1. customOrganic volatile fractions were removed on a rotary evaporator
2. extractionThe remaining aqueous phase was extracted with methyl tert-butyl ether (MTBE)
3. filtrationThe resulting precipitate was filtered off
4. customdried
5. customThe product was thus obtained with the molecular weight of 222.24 (C12H14O4)