Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylparaben | HCID 7456 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | (S)-1-(tetrahydrofuran-2-yl)methyl methanesulfonate | HCID 18649743 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 67545132 | HCID 67545132 | — |
Reaction Steps
A mixture of methanesulfonic acid (S)-1-(tetrahydrofuran-2-yl)methyl ester (7.6 g), 4-hydroxybenzoic acid methyl ester (6.4 g), cesium carbonate (20 g) and NMP (100 ml) was heated to 75° C. for 12 hours. The cooled reaction mixture was admixed with water and extracted with ethyl acetate. The organic phase was washed three times with water, dried over magnesium sulfate and concentrated. The product was thus obtained with the molecular weight of 236.27 (C13H16O4); MS (ESI): 237 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08609731B2 |
|---|
| Source dataset | uspto-grants-2013_12 |
|---|
| ORD ID | ord-cc8bd558ea774d2eb5a41f26b98b3749 |
|---|
| Source note | uspto-grants-2013_12 |
|---|
