(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuran → (RS)-4-(3,4-Dimethyl-benzyl)-1-(5-benzyloxy-2,3-dihydro-benzofuran-2-ylmethyl)-piperidin-4-ol

HRID 191382Notes

Reaction equation

HRID 191382 reaction equation
[CH2:17]([c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1)[O:24][c:25]1[cH:26][cH:27][c:28]2[c:29]([cH:35]1)[CH2:30][CH:31]([CH2:33][Br:34])[O:32]2.[CH3:1][c:2]1[cH:3][c:4]([CH2:5][C:6]2([OH:12])[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]2)[cH:13][cH:14][c:15]1[CH3:16]>>[CH3:1][c:2]1[cH:3][c:4]([CH2:5][C:6]2([OH:12])[CH2:7][CH2:8][N:9]([CH2:33][CH:31]3[CH2:30][c:29]4[c:28]([cH:27][cH:26][c:25]([O:24][CH2:17][c:18]5[cH:19][cH:20][cH:21][cH:22][cH:23]5)[cH:35]4)[O:32]3)[CH2:10][CH2:11]2)[cH:13][cH:14][c:15]1[CH3:16]

Participants

3

Reactant 2

HCID 22628347(RS)-5-Benzyloxy-2-bromomethyl-2,3-dihydro-benzofuranHCID 226283974-(3,4-Dimethyl-benzyl)-piperidin-4-ol

Product 1

HCID 22628380(RS)-4-(3,4-Dimethyl-benzyl)-1-(5-benzyloxy-2,3-dihydro-benzofuran-2-ylmethyl)-piperidin-4-ol

Sources & evidence

ORD record
ord-62dfd233bb914b97b75c9e42937551f6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…