HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-1-(tetrahydrofuran-2-yl)methyl methanesulfonate → 5-[(S)-1-(Tetrahydrofuran-2-yl)methoxy]pyridine-2-carboxylic acid ((S)-6-azepan-1-ylmethyl-1,2,3,4-tetrahydronaphthalen-2-yl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-1-(tetrahydrofuran-2-yl)methyl methanesulfonate | HCID 18649743 | — |
| Reactant | 5-hydroxypyridine-2-carboxylic acid ((S)-6-azepan-1-ylmethyl-1,2,3,4-tetrahydronaphthalen-2-yl)amide | HCID 86645829 | — |
| Product | 5-[(S)-1-(Tetrahydrofuran-2-yl)methoxy]pyridine-2-carboxylic acid ((S)-6-azepan-1-ylmethyl-1,2,3,4-tetrahydronaphthalen-2-yl)amide | HCID 59505768 | — |
Reaction Steps
According to method F, 5-hydroxypyridine-2-carboxylic acid ((S)-6-azepan-1-ylmethyl-1,2,3,4-tetrahydronaphthalen-2-yl)amide was alkylated with methanesulfonic acid (S)-1-(tetrahydrofuran-2-yl)methyl ester (DMF, 12 h, 80° C.). The product was thus obtained with the molecular weight of 463.63 (C28H37N3O3); MS (ESI): 464 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609731B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-246dee9ac1f848ddb9fe53207d7abec0 |
| Source note | uspto-grants-2013_12 |