HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-fluoro-4-hydroxybenzoate → 3-Fluoro-4-[(S)-1-(tetrahydrofuran-2-yl)methoxy]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-fluoro-4-hydroxybenzoate | HCID 13745619 | — |
| Reactant | (S)-1-(tetrahydrofuran-2-yl)methyl methanesulfonate | HCID 18649743 | — |
| Product | 3-Fluoro-4-[(S)-1-(tetrahydrofuran-2-yl)methoxy]benzoic acid | HCID 28604871 | — |
Reaction Steps
According to method F, 3-fluoro-4-hydroxybenzoic acid ethyl ester was alkylated with methanesulfonic acid (S)-1-(tetrahydrofuran-2-yl)methyl ester, and the reaction product was hydrolyzed by method E. The product was thus obtained with the molecular weight of 240.23 (C12H13FO4); MS (ESI): 241 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609731B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-9332a8580de44b0785f302af0b42a027 |
| Source note | uspto-grants-2013_12 |