HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1913830Generated: October 25, 2026
Water → 6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]isochromen-1-one
https://huagongshe.com/reaction/1913830
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | (S)-1-(tetrahydrofuran-2-yl)methyl methanesulfonate | HCID 18649743 | — |
| Reactant | 6-Hydroxyisochromen-1-one | HCID 66879699 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]isochromen-1-one | HCID 66879690 | — |
Reaction Steps
To a solution of 6-hydroxyisochromen-1-one (2 g) in DMF (50 ml) were added methanesulfonic acid (S)-1-(tetrahydrofuran-2-yl)methyl ester (2.7 g) and cesium carbonate (12 g), and the mixture was stirred at 80° C. for 7 hours. After water had been added, the mixture was extracted with dichloromethane. The organic phases were dried over magnesium sulfate and concentrated. The product was thus obtained with the molecular weight of 246.27 (C14H14O4); MS (ESI): 247 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08609731B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-845ddf2eb1354a338834718f55a67c95 |
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| Source note | uspto-grants-2013_12 |
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