(S)-1-(tetrahydrofuran-2-yl)methyl methanesulfonate → HCID 59505961, compound

HRID 1913834Notes

Reaction equation

HRID 1913834 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([C@H:13]1[CH2:22][CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([CH2:23][N:24]4[CH2:29][CH2:28][CH:27]([O:30][CH3:31])[CH2:26][CH2:25]4)[CH:19]=3)[CH2:14]1)[CH2:6][CH2:5]2.[O:32]1[CH2:36][CH2:35][CH2:34][C@H:33]1[CH2:37]OS(C)(=O)=O>>[CH3:31][O:30][CH:27]1[CH2:26][CH2:25][N:24]([CH2:23][C:18]2[CH:19]=[C:20]3[C:15](=[CH:16][CH:17]=2)[CH2:14][C@@H:13]([N:7]2[CH2:6][CH2:5][C:4]4[C:9](=[CH:10][CH:11]=[C:2]([O:1][CH2:37][C@@H:33]5[CH2:34][CH2:35][CH2:36][O:32]5)[CH:3]=4)[C:8]2=[O:12])[CH2:22][CH2:21]3)[CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 18649743(S)-1-(tetrahydrofuran-2-yl)methyl methanesulfonateHCID 67544865HCID 67544865, compound

Product 1

HCID 59505961HCID 59505961, compound

Procedure

According to method F, 6-hydroxy-2-[(S)-6-(4-methoxypiperidin-1-ylmethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]-3,4-dihydro-2H-isoquinolin-1-one was alkylated with methanesulfonic acid (S)-1-(tetrahydrofuran-2-yl)methyl ester. The product was thus obtained with the molecular weight of 504.68 (C31H40N2O4); MS (ESI): 505 (M+H+).

Workup

  1. customThe product was thus obtained with the molecular weight of 504.68 (C31H40N2O4)

Sources & evidence

ORD record
ord-9fda259a4dcb4a8a92a623deb9238ef8
Source dataset
uspto-grants-2013_12
Patent number
US08609731B2

Reaction notes

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