Thiophenol → HCID 67544865, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-methoxy-2-[(S)-6-(4-methoxypiperidin-1-ylmethyl)-1,2,3,4-tetrahydronaphthalen-2-yl]-3,4-dihydro-2H-isoquinolin-1-one (0.59 g), NMP (2 ml), thiophenol (150 mg) and potassium carbonate (235 mg) was heated to 210° C. in a microwave reactor for 40 minutes. The cooled reaction mixture was purified by chromatography on silica gel (eluent: 9:1 dichloromethane/methanol). The product was thus obtained with the molecular weight of 420.56 (C26H32N2O3); MS (ESI): 421 (M+H+).

Provenance & Evidence