Methanol → HCID 55269558, compound

HRID 1913874Notes

Reaction equation

HRID 1913874 reaction equation
[NH2:1][CH2:2][CH2:3][CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1F)[OH:5].[CH3:13][OH:14]>>[NH2:1][CH2:2][CH2:3][CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:14][CH3:13])[OH:5]

Participants

3

Reactant 2

HCID 887MethanolHCID 64982940HCID 64982940, compound

Product 1

HCID 55269558HCID 55269558, compound

Procedure

3-Amino-1-(2-methoxy-phenyl)-propan-1-ol was prepared by the same procedure as 3-amino-1-(2-fluoro-phenyl)-propan-1-ol without adding methanol in the acidification step in example 6. 1H NMR (DMSO-d6) δ 7.45-7.19 (m, 1H), 7.11-7.08 (m, 3H), 6.48 (s, 2H), 6.40 (t, J=7.1 Hz, 1H), 5.10 (d, J=4.7 Hz, 1H), 4.83-4.75 (m, 1H), 3.05-2.95 (m, 2H), 2.25 (s, 3H), 1.81-1.62 (m, 2H).

Sources & evidence

ORD record
ord-9a400bb95f8f402a8ccb65c43144d605
Source dataset
uspto-grants-2013_12
Patent number
US08609849B1

Reaction notes

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