Hydrochloric Acid → HCID 68789286, compound

Participants

Reaction Steps

To a solution of 6-[(1-cyclobutylpiperidin-4-yl)oxy]-1-(4-fluorophenyl)-3,4-dihydroquinolin-2(1H)-one (Compound No. 60) prepared in Example 6 (0.90 g) in a mixture of ethyl acetate (10 mL) and ethanol (2 mL), 4N hydrochloric acid in ethyl acetate (1.14 mL) was added and stirred at room temperature for 3 hours. The reaction mixture was concentrated under reduced pressure, followed by addition of isopropanol (7 mL) and ethanol (2 mL) to the residue. The mixture was stirred for 5 minutes while heating in an oil bath (110° C.), and then stirred while cooling to room temperature. The precipitate was collected by filtration and dried to give the titled compound (0.93 g, 95%) as a colorless crystal.

Provenance & Evidence