Hydrochloric Acid → HCID 66684102, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-(1-(4-fluorophenyl)-2-oxo-1,2,3,4-tetrahydroquinolin-6-yloxy)piperidine-1-carboxylate prepared in Example 7-(2) (6.0 g) in a mixture of ethyl acetate (12 mL) and ethanol (4 mL), 4M hydrochloric acid in ethyl acetate (10 mL) was added dropwise at room temperature and stirred for 16 hours. The reaction mixture was concentrated under reduced pressure, diluted with ethyl acetate and stirred at room temperature for 1 hour. The precipitate was collected by filtration and dried to give the titled compound (5.1 g, 99%) as a colorless solid.

Provenance & Evidence