反应详情

Benzyl 4-amino-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)picolinate (3.00 g, 7.41 mmol) was added to CH3OH (35 mL). Sodium methoxide (25 wt % in CH3OH; 2.0 mL, 8.9 mmol) was added to the reaction mixture and allowed to stir for 24 h. Water (50 mL) was added to the reaction mixture and the mixture was concentrated under reduced pressure to remove most of the CH3OH. The mixture was extracted with EtOAc (2×40 mL), and the combined organic layers were washed with water (40 mL) and satd sodium chloride (40 mL) and concentrated under reduced pressure to provide methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoropicolinate as a pale yellow solid (1.86 g; 67% purity by LC area).

1. concentrationthe mixture was concentrated under reduced pressure
2. customto remove most of the CH3OH
3. extractionThe mixture was extracted with EtOAc (2×40 mL)
4. washthe combined organic layers were washed with water (40 mL) and satd sodium chloride (40 mL)
5. concentrationconcentrated under reduced pressure