1,2-Dichloroethane → HCID 25256061, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(2-morpholin-4-yl-9-pyrrolidin-3-yl-9H-purin-6-yl)-pyrimidin-2-ylamine (37 mg, 0.08 mmol) in DMF was added 5-methyl-thiophene-2-carboxylic acid (15 mg, 0.104 mmol, 1.3 eq), EDC (20 mg, 0.104 mmol, 1.3 eq), HOBt (14 mg, 0.104 mmol, 1.3 eq) and diisopropylethylamine (32 μL, 0.184 mmol, 2.3 eq). The mixture was stirred at 50° C. for 16 hrs. Then NaHCO3 was added and the mixture extracted twice with ethyl acetate. The combined organic layers were further washed with brine before drying over Na2SO4. The crude product was purified by chromatography to afford the title compound as yellow solid (14.4 mg).

Provenance & Evidence