HCID 53248331, compound → HCID 18603236, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (5) (1.00 g, 3.89 mmol) in acetone (40 mL) at 0° C. was added a freshly prepared solution of Jones Reagent (2.5 M, 3.89 mL, 9.71 mmol) and the reaction was stirred at 0° C. for 1 h. The dark solution was extracted with Et2O (3×50 mL), the organic layers washed with water (2×75 mL), brine (1×50 mL), dried (Na2SO4), filtered and concentrated to yield 990 mg (94% crude) of acid (6) as a yellow oil that was used without further purification.

Provenance & Evidence