反应详情

Chloroacetyl chloride in diethylether was added dropwise to N-methyloctylamine in diethylether at −2° C. The organic solution was returned to room temperature, followed by stirring for 3 hours. The resulting solution was successively washed with an aqueous 1 mol/L hydrochloric acid solution and water, and then dried over anhydrous sodium sulfate. After removal the solvent under vacuum, the residue was purified by silica gel column chromatography (hexane:ethyl acetate=23:2) to give N-methyl-N-octyl-chloroacetamide (yield: 66.4%).

1. customwas returned to room temperature
2. washThe resulting solution was successively washed with an aqueous 1 mol/L hydrochloric acid solution and water
3. dry with materialdried over anhydrous sodium sulfate
4. customAfter removal the solvent under vacuum
5. customthe residue was purified by silica gel column chromatography (hexane:ethyl acetate=23:2)