HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Naphthalenesulfonyl chloride → 5-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-[1-(naphthalen-1-ylsulfonyl)piperidin-4-yl]-2,4-dihydro-3H-pyrazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Naphthalenesulfonyl chloride | HCID 66560 | — |
| Reactant | 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride | HCID 66616406 | — |
| Product | 5-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-[1-(naphthalen-1-ylsulfonyl)piperidin-4-yl]-2,4-dihydro-3H-pyrazol-3-one | HCID 46202393 | — |
Reaction Steps
The title compound is prepared analogously as described for GP1 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B1*HCl) and naphthalene-1-sulfonyl chloride as starting compounds. The crude product is purified by crystallization from methanol to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609848B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-cc33a5422fe0431983f50d2633382c59 |
| Source note | uspto-grants-2013_12 |