2-Cyanobenzenesulfonyl Chloride → HCID 46203677, compound

HRID 1914089Notes

Reaction equation

HRID 1914089 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:16]3([CH2:20][CH2:19][CH2:18][CH2:17]3)[C:15](=[O:21])[N:14]([CH:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)[N:13]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11].[C:28]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[S:36](Cl)(=[O:38])=[O:37])#[N:29]>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:16]3([CH2:17][CH2:18][CH2:19][CH2:20]3)[C:15](=[O:21])[N:14]([CH:22]3[CH2:23][CH2:24][N:25]([S:36]([C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=4[C:28]#[N:29])(=[O:38])=[O:37])[CH2:26][CH2:27]3)[N:13]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

3

Reactant 2

HCID 5223472-Cyanobenzenesulfonyl ChlorideHCID 66616531HCID 66616531, compound

Product 1

HCID 46203677HCID 46203677, compound

Procedure

The title compound is prepared analogously as described for GP1 using 4-(3,4-dimethoxyphenyl)-2-(piperidin-4-yl)-2,3-diazaspiro[4.4]non-3-en-1-one hydrochloride (compound B10*HCl) and 2-cyanobenzenesulfonyl chloride as starting compounds. The crude product is purified by crystallization from EA and diethyl ether to yield the title compound.

Workup

  1. customThe title compound is prepared analogously
  2. customThe crude product is purified by crystallization from EA and diethyl ether

Sources & evidence

ORD record
ord-229f50b5b7ae4c1182ae09ccce74881c
Source dataset
uspto-grants-2013_12
Patent number
US08609848B2

Reaction notes

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