HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,6-Dimethoxypyridine-3-carboxylic acid → 5-(3,4-Dimethoxyphenyl)-2-{1-[(2,6-dimethoxypyridin-3-yl)carbonyl]piperidin-4-yl}-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2,6-Dimethoxypyridine-3-carboxylic acid | HCID 853178 | — |
| Edukt | 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride | HCID 66616406 | — |
| Produkt | 5-(3,4-Dimethoxyphenyl)-2-{1-[(2,6-dimethoxypyridin-3-yl)carbonyl]piperidin-4-yl}-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one | HCID 46204339 | — |
Reaktionsschritte
The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and 2,6-dimethoxynicotinic acid as starting compounds. The crude product is purified by chromatography (silica gel and DCM/diethyl ether/methanol=7:3:2) to yield the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08609848B2 |
| Quelldatensatz | uspto-grants-2013_12 |
| ORD ID | ord-4e71c924096340cd9312e542a7de2a69 |
| Quellennotiz | uspto-grants-2013_12 |