HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Quinolinecarboxylic acid → HCID 46205297, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Quinolinecarboxylic acid | HCID 82571 | — |
| Reactant | 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride | HCID 66616406 | — |
| Product | HCID 46205297 | HCID 46205297 | — |
Reaction Steps
The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and quinoline-6-carboxylic acid as starting compounds. The crude product is purified by chromatography (amino phase silica gel and DCM) and by crystallization from DCM and diethyl ether to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609848B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-dfc30c2eec214aae97bf6daa4cab7051 |
| Source note | uspto-grants-2013_12 |