HRID1914166

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18525782

1-Methyl-1H-indole-4-sulfonyl chloride

C9H8ClNO2S

结构：COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)c2c1OC(C)(C)C2.Cl

HCID66616590

未命名化合物

2 次

PRODUCTS

生成物

结构：COc1ccc(C2=NN(C3CCN(S(=O)(=O)c4cccc5c4ccn5C)CC3)C(=O)C2(C)C)c2c1OC(C)(C)C2

HCID67365062

未命名化合物

PROCEDURE

实验过程

The title compound is prepared analogously as described for GP1 using 5-(7-methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-4-yl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B5*HCl) and 1-methyl-1H-indole-4-sulfonyl chloride as starting compounds. The crude product is purified by crystallization from methanol to yield the title compound.

WORKUP

后处理

customThe title compound is prepared analogously
customThe crude product is purified by crystallization from methanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-935cc6dcb19f4b2db438f65ffd824d18
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08609848B2
来源说明: uspto-grants-2013_12

反应 SMILES

Cl.[CH3:2][O:3][C:4]1[C:12]2[O:11][C:10]([CH3:14])([CH3:13])[CH2:9][C:8]=2[C:7]([C:15]2[C:16]([CH3:28])([CH3:27])[C:17](=[O:26])[N:18]([CH:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)[N:19]=2)=[CH:6][CH:5]=1.[CH3:29][N:30]1[C:38]2[CH:37]=[CH:36][CH:35]=[C:34]([S:39](Cl)(=[O:41])=[O:40])[C:33]=2[CH:32]=[CH:31]1>>[CH3:2][O:3][C:4]1[C:12]2[O:11][C:10]([CH3:14])([CH3:13])[CH2:9][C:8]=2[C:7]([C:15]2[C:16]([CH3:28])([CH3:27])[C:17](=[O:26])[N:18]([CH:20]3[CH2:25][CH2:24][N:23]([S:39]([C:34]4[CH:35]=[CH:36][CH:37]=[C:38]5[C:33]=4[CH:32]=[CH:31][N:30]5[CH3:29])(=[O:40])=[O:41])[CH2:22][CH2:21]3)[N:19]=2)=[CH:6][CH:5]=1