化工社化工社 化学情報印刷レポート · 研究参考用
3-Methylbenzenesulphonyl chloride → 5-(3,4-Diethoxyphenyl)-4,4-dimethyl-2-{1-[(3-methylphenyl)sulfonyl]piperidin-4-yl}-2,4-dihydro-3H-pyrazol-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methylbenzenesulphonyl chloride | HCID 2734595 | — |
| 反応物 | 5-(3,4-diethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride | HCID 66616549 | — |
| 生成物 | 5-(3,4-Diethoxyphenyl)-4,4-dimethyl-2-{1-[(3-methylphenyl)sulfonyl]piperidin-4-yl}-2,4-dihydro-3H-pyrazol-3-one | HCID 67363337 | — |
反応手順
The title compound is prepared analogously as described for GP1 using 5-(3,4-diethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B2*HCl) and 3-methylbenzenesulfonyl chloride as starting compounds. The crude product is purified by crystallization from methanol to yield the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08609848B2 |
| 出典データセット | uspto-grants-2013_12 |
| ORD ID | ord-11861e60098741f9aaa264495cb99357 |
| 出典メモ | uspto-grants-2013_12 |