HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methylbenzenesulphonyl chloride → 5-(3,4-Dimethoxyphenyl)-4-methyl-2-{1-[(3-methylphenyl)sulfonyl]piperidin-4-yl}-4-propyl-2,4-dihydro-3H-pyrazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methylbenzenesulphonyl chloride | HCID 2734595 | — |
| Reactant | 5-(3,4-dimethoxyphenyl)-4-methyl-2-piperidin-4-yl-4-propyl-2,4-dihydro-3H-pyrazol-3-one hydrochloride | HCID 66616509 | — |
| Product | 5-(3,4-Dimethoxyphenyl)-4-methyl-2-{1-[(3-methylphenyl)sulfonyl]piperidin-4-yl}-4-propyl-2,4-dihydro-3H-pyrazol-3-one | HCID 67365940 | — |
Reaction Steps
The title compound is prepared analogously as described for GP1 using 5-(3,4-dimethoxyphenyl)-4-methyl-2-piperidin-4-yl-4-propyl-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B8*HCl) and 3-methylbenzenesulfonyl chloride as starting compounds. The crude product is purified by crystallization from methanol to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609848B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-51693a2126b845f788847c4e0a8260a8 |
| Source note | uspto-grants-2013_12 |