1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine → 5-(3,4-diethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one

HRID 1914222노트

반응식

HRID 1914222 반응식
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:13]2[C:14]([CH3:20])([CH3:19])[C:15](=[O:18])[NH:16][N:17]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH3:12])[CH3:2].CC1C=CC(S(O[CH:32]2[CH2:37][CH2:36][N:35](C(OC(C)(C)C)=O)[CH2:34][CH2:33]2)(=O)=O)=CC=1>>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:13]2[C:14]([CH3:20])([CH3:19])[C:15](=[O:18])[N:16]([CH:32]3[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]3)[N:17]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH3:12])[CH3:2]

참가 물질

3

반응물 2

HCID 157347131-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine2회HCID 666164935-(3,4-diethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one2회

생성물 1

HCID 666165505-(3,4-diethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one

실험 절차

Prepared analogously as described for the example B1 (Alternative 1) using 5-(3,4-diethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (compound C2) and tert-butyl 4-(Toluene-4-sulfonyloxy)piperidine-1-carboxylate (compound E1) as starting compounds resulting in the hydrochloride salt of the title compound. (compound B2*HCl)

후처리

  1. customPrepared analogously

출처 및 근거

ORD 기록
ord-ff33ce68043d4defb834daebac2d9677
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609848B2

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