1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine → HCID 66616631, compound

HRID 1914229Notes

Reaction equation

HRID 1914229 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:12]([CH2:18][CH3:19])([CH3:17])[C:13](=[O:16])[NH:14][N:15]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].CC1C=CC(S(O[CH:31]2[CH2:36][CH2:35][N:34](C(OC(C)(C)C)=O)[CH2:33][CH2:32]2)(=O)=O)=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:12]([CH2:18][CH3:19])([CH3:17])[C:13](=[O:16])[N:14]([CH:31]3[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]3)[N:15]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 157347131-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine2×HCID 66616447HCID 66616447, compound2×

Product 1

HCID 66616631HCID 66616631, compound

Procedure

Prepared analogous as described for the example B1 (Alternative 1) using 5-(3,4-dimethoxyphenyl)-4-ethyl-4-methyl-2,4-dihydro-3H-pyrazol-3-one (compound C9) and tert-butyl 4-(Toluene-4-sulfonyloxy)piperidine-1-carboxylate (compound E1) as starting compounds resulting in the hydrochloride salt of the title compound. (compound B9*HCl)

Workup

  1. customPrepared analogous

Sources & evidence

ORD record
ord-2fb86ce8056a4e5e8b4ea763e4d5da11
Source dataset
uspto-grants-2013_12
Patent number
US08609848B2

Reaction notes

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